CD25 (IL-2 receptor alpha)
CD25 is the part of the interleukin-2 receptor found on activated T cells and on some lymphoma cells; denileukin diftitox uses it as a doorway to deliver a toxin. This dossier gathers the 1 product (1 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Biology
CD25 confers high-affinity IL-2 binding; its density on regulatory T cells makes it a candidate for depleting immunosuppressive cells in the tumour microenvironment.
- Cutaneous T-cell lymphoma (about half of cases express CD25)
- Adult T-cell leukaemia/lymphoma
- Hodgkin lymphoma (Reed-Sternberg cells)
Elsewhere: identifiers and databases
Built from HGNC, Ensembl, UniProt and ChEMBL idsProducts by modality and phase
Browse products →| Modality | Approved |
|---|---|
| IL-2 receptor-directed cytotoxin 1 |
Trials
Evidence ranking →No trial in the corpus names this target or one of its products.
Resistance routes that involve this target
Unaddressed routes →The resistance atlas has no route that names this target.
Pathways where it is a node
Pathway-to-drug matrix →No pathway diagram carries this target as a node.
Companion diagnostics and assays
Assay registry →No companion diagnostic in the registry measures this target.
Preclinical models
All models →No model entry for this target yet; check the cancer entries on the models page.
Open questions
All open questions →No open questions recorded for this target yet. Suggest one.
Ideas and companies
Key papers and the live literature
Preprints →Query for this target: (TITLE:"CD25" OR ABSTRACT:"CD25" OR TITLE:"IL-2 receptor alpha" OR ABSTRACT:"IL-2 receptor alpha" OR TITLE:"IL2RA" OR ABSTRACT:"IL2RA") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CD25 (IL-2 receptor alpha), not a curated reading list.
Export
The dossier as machine-readable JSON: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/cd25.json. Licence CC BY-NC 4.0.