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AST-202 is an experimental aptamer-drug conjugate from Aptamer Sciences, in preclinical development for blood cancers and solid tumours.
AST-202 is an aptamer-drug conjugate (ApDC) from Aptamer Sciences. A CD25-binding aptamer joined to a cytotoxic drug, designed to deplete regulatory T cells in tumours and to act directly on blood cancers that overexpress CD25. Its furthest stage is preclinical development, for blood cancers and solid tumours. No clinical trial naming it is registered on ClinicalTrials.gov. It has not been shown to work in people.
A CD25-binding aptamer joined to a cytotoxic drug, designed to deplete regulatory T cells in tumours and to act directly on blood cancers that overexpress CD25. Connects to CD25 (IL-2 receptor alpha).
1.AST-202's antibody arm binds CD25 (IL-2 receptor alpha) on the surface of the cancer cell.
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Query for this drug: (TITLE:"AST-202" OR ABSTRACT:"AST-202") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about AST-202, not a curated reading list.
Shares CD25 (IL-2 receptor alpha), Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares Aptamer Sciences, Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares Aptamer Sciences, Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares CD25 (IL-2 receptor alpha) and the tag pipeline.
Shares Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares Metastatic cancer (cancer that has spread) and the tag pipeline.
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