Loading
AST-201 is an experimental aptamer-drug conjugate from Aptamer Sciences, in phase 1 trials for hepatocellular carcinoma and GPC3-positive advanced solid tumours.
AST-201 is an aptamer-drug conjugate (ApDC) from Aptamer Sciences. A DNA aptamer that binds GPC3 with gemcitabine built into its sequence; once taken into the cell it releases the active gemcitabine form, designed to get round known gemcitabine resistance mechanisms. Its furthest stage is phase 1, for hepatocellular carcinoma and GPC3-positive advanced solid tumours. ClinicalTrials.gov registers it in one study linked below. Whether it works in people has not been established unless a trial below reports it.
A DNA aptamer that binds GPC3 with gemcitabine built into its sequence; once taken into the cell it releases the active gemcitabine form, designed to get round known gemcitabine resistance mechanisms. Connects to Glypican-3.
1.AST-201's antibody arm binds Glypican-3 on the surface of the cancer cell.
Background: ADC sequencing, Antigen escape (antigen loss, lineage switch), BCG-unresponsive, Castration-resistant prostate cancer (CRPC), Circulating tumour DNA (ctDNA). Also on OnCo: Resistance: how tumours escape each drug class · Lines of therapy.
Country and place are remembered in this browser only. A postcode is sent to OpenStreetMap's Nominatim service to find coordinates when you press the button; nothing else leaves your device.
Query for this drug: (TITLE:"AST-201" OR ABSTRACT:"AST-201") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about AST-201, not a curated reading list.
Shares Aptamer Sciences, Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares Glypican-3, Hepatocellular carcinoma and the tag pipeline.
Shares Hepatocellular carcinoma, Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares Hepatocellular carcinoma, Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares Hepatocellular carcinoma, Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares Hepatocellular carcinoma, Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares Hepatocellular carcinoma, Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares Hepatocellular carcinoma, Metastatic cancer (cancer that has spread) and the tag pipeline.
Every source this page cites, grouped by who published it. Grouping is read from the web address, not assigned by hand.
A source that has moved or gone is reported by the weekly link check. /audit/