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PLK4 is the enzyme that starts the copying of the centrosome, the structure that organises a dividing cell's spindle. Cancers with extra copies of the TRIM37 gene cannot divide properly once PLK4 is blocked, and two PLK4 inhibitors are in early trials. This dossier gathers the 2 products (0 approved), 7 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Kinase that initiates procentriole formation on the parental centriole and recruits centriole-building proteins such as SASS6 and CPAP; overexpression produces multiple procentrioles per parent centriole (UniProt O00444).
| Modality | Phase 2 | Phase 1 |
|---|---|---|
| Small molecule 2 |
| Trial | Setting | Result | Products | ||
|---|---|---|---|---|---|
| 2 | Active | A Phase II Study of CFI-400945 and Durvalumab in Patients With Advanced/Metastatic Triple Negative Breast Cancer (TNBC) | - | ||
| 2 | Active | A Phase II Study of CFI-400945 in Patients With Advanced/Metastatic Breast Cancer | - | ||
| 2 | Recruiting | A Liquid-biopsy Informed Platform Trial to Evaluate Treatment in CDK4/6-inhibitor Resistant ER+/HER2- Metastatic Breast Cancer | - | ||
| 2 | Active | Prostate Cancer Biomarker Enrichment and Treatment Selection (PC-BETS) Study | - | ||
| 1 | Completed | An Open Label, Dose Escalation, Safety, and Pharmacokinetic Study of CFI-400945 Fumarate Administered Orally to Patients With Advanced Cancer | - | ||
| 1 | Historic | Phase 1 Trial of the Safety, Pharmacokinetics, Pharmacodynamics, and Preliminary Clinical Activity of RP-1664 in Participants With Advanced Solid Tumors | - | ||
| 1 | Completed | An Open-Label, Dose Escalation, Safety and Pharmacokinetic Study of CFI-400945 Fumarate Administered Orally to Patients With Relapsed or Refractory Acute Myeloid Leukemia or Myelodysplastic Syndrome | - |
No recorded escape route names this target.
No pathway diagram carries this target as a node.
No companion diagnostic in the registry measures this target.
No model entry for this target yet; check the cancer entries on the models page.
No open questions recorded for this target yet. Suggest one.
Query for this target: (TITLE:"PLK4" OR ABSTRACT:"PLK4" OR TITLE:"polo like kinase 4" OR ABSTRACT:"polo like kinase 4" OR TITLE:"polo-like kinase 4" OR ABSTRACT:"polo-like kinase 4" OR TITLE:"STK18" OR ABSTRACT:"STK18") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PLK4, not a curated reading list.
The dossier as machine-readable JSON, at /api/v1/dossiers/plk4.json: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/plk4.json. Licence CC BY-NC 4.0.