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Gintemetostat is an experimental small molecule from K36 Therapeutics, in phase 1 trials for relapsed or refractory multiple myeloma).
Gintemetostat (KTX-1001) is a small molecule (oral) from K36 Therapeutics. An oral, selective inhibitor of NSD2 (also called MMSET or WHSC1), which is overexpressed in multiple myeloma with the t(4;14) translocation; it is designed to reduce H3K36me2 levels and reverse oncogenic transcriptional programmes. Its furthest stage is phase 1, for relapsed or refractory multiple myeloma (t(4;14)). ClinicalTrials.gov registers it in one study linked below. NCT05651932 (K36-MMSET-001) recruiting per v2 API, with combination cohorts. Whether it works in people has not been established unless a trial below reports it.
An oral, selective inhibitor of NSD2 (also called MMSET or WHSC1), which is overexpressed in multiple myeloma with the t(4;14) translocation; it is designed to reduce H3K36me2 levels and reverse oncogenic transcriptional programmes. Connects to NSD2.
1.Gintemetostat slips into a pocket on NSD2.
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Query for this drug: (TITLE:"Gintemetostat" OR ABSTRACT:"Gintemetostat" OR TITLE:"KTX-1001" OR ABSTRACT:"KTX-1001") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Gintemetostat, not a curated reading list.
Shares K36 Therapeutics, NSD2 and the tag pipeline.
Shares K36 Therapeutics and the tag pipeline.
Shares Relapsed or refractory multiple myeloma and the tag pipeline.
Shares Relapsed or refractory multiple myeloma and the tag pipeline.
Shares Relapsed or refractory multiple myeloma and the tag pipeline.
Shares Relapsed or refractory multiple myeloma and the tag pipeline.
Shares Relapsed or refractory multiple myeloma and the tag pipeline.
Shares Relapsed or refractory multiple myeloma and the tag pipeline.
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