Loading
KTX-2001 is an experimental small molecule from K36 Therapeutics, in phase 1 trials for metastatic castration-resistant prostate cancer.
KTX-2001 (KTX2001) is a small molecule (oral) from K36 Therapeutics. An oral, selective NSD2 inhibitor that blocks NSD2 methylation of histone H3 at lysine 36 (H3K36), tested alone and with the androgen receptor pathway inhibitor darolutamide. Its furthest stage is phase 1, for metastatic castration-resistant prostate cancer. ClinicalTrials.gov registers it in one study linked below. NCT07103018 (STRIKE-001) recruiting per v2 API. Whether it works in people has not been established unless a trial below reports it.
An oral, selective NSD2 inhibitor that blocks NSD2 methylation of histone H3 at lysine 36 (H3K36), tested alone and with the androgen receptor pathway inhibitor darolutamide. Connects to NSD2.
1.KTX-2001 slips into a pocket on NSD2.
Background: ADC sequencing, Antigen escape (antigen loss, lineage switch), BCG-unresponsive, Castration-resistant prostate cancer (CRPC), Circulating tumour DNA (ctDNA). Also on OnCo: Resistance: how tumours escape each drug class · Lines of therapy.
Country and place are remembered in this browser only. A postcode is sent to OpenStreetMap's Nominatim service to find coordinates when you press the button; nothing else leaves your device.
Query for this drug: (TITLE:"KTX-2001" OR ABSTRACT:"KTX-2001" OR TITLE:"KTX2001" OR ABSTRACT:"KTX2001") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about KTX-2001, not a curated reading list.
Shares K36 Therapeutics, NSD2 and the tag pipeline.
Shares K36 Therapeutics and the tag pipeline.
Shares Metastatic castration-resistant prostate cancer and the tag pipeline.
Shares Metastatic castration-resistant prostate cancer and the tag pipeline.
Shares Metastatic castration-resistant prostate cancer and the tag pipeline.
Shares Metastatic castration-resistant prostate cancer and the tag pipeline.
Shares Metastatic castration-resistant prostate cancer and the tag pipeline.
Shares Metastatic castration-resistant prostate cancer and the tag pipeline.
Every source this page cites, grouped by who published it. Grouping is read from the web address, not assigned by hand.
A source that has moved or gone is reported by the weekly link check. /audit/