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A tissue test for stage II and some stage III colon cancers that estimates how likely the cancer is to come back after surgery.
Exact Sciences states that "This 12-gene test, with 7 cancer-related genes and 5 reference genes" is "clinically validated to quantify the risk of recurrence in patients with anatomic stage II, T3 or T4, MMR-P, or stage III A/B colon cancers". In the QUASAR validation of 1,436 patients with stage II colon cancer, three-year recurrence risks were 12, 18 and 22 per cent in the low, intermediate and high groups, and the treatment score did not predict benefit from chemotherapy (Gray 2011). Palmetto MolDX article A53106 gives billing instructions for it under CPT 81525, whose code descriptor reads "mRNA gene expression of 21 genes", which does not match the maker's 12 genes; the article does not itself state coverage.
Reverse-transcription PCR of seven cancer-related and five reference genes in resected colon tumour tissue gives a recurrence score.
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Query for this drug: (TITLE:"Oncotype DX Colon Recurrence Score" OR ABSTRACT:"Oncotype DX Colon Recurrence Score" OR TITLE:"Oncotype DX Colon" OR ABSTRACT:"Oncotype DX Colon" OR TITLE:"Oncotype DX Colon Cancer Assay" OR ABSTRACT:"Oncotype DX Colon Cancer Assay") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Oncotype DX Colon Recurrence Score, not a curated reading list.
Shares Exact Sciences (Abbott), Gene-expression prognostic assays, Oncotype DX, RNA sequencing & expression profiling and the tags test, rna.
Shares Gene-expression prognostic assays, RNA sequencing & expression profiling and the tags test, rna.
Shares Gene-expression prognostic assays, RNA sequencing & expression profiling and the tags test, rna.
Shares Gene-expression prognostic assays, RNA sequencing & expression profiling and the tags test, rna.
Shares Gene-expression prognostic assays and the tags test, rna.
Shares Gene-expression prognostic assays and the tags test, rna.
Shares Gene-expression prognostic assays and the tags test, rna.
Shares RNA sequencing & expression profiling and the tags test, rna.
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