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PLX-61639 is an experimental oral monovalent direct protein degrader from Plexium, in phase 1 trials for SMARCA4-mutant locally advanced or metastatic solid tumours, non-small cell lung cancer and oesophageal and gastric cancers.
PLX-61639 is an oral monovalent direct protein degrader from Plexium. An oral SMARCA2-selective degrader that uses a tissue-restricted E3 ligase; tumours that have lost SMARCA4 depend on SMARCA2, so removing it is synthetically lethal for them. Its furthest stage is phase 1, for SMARCA4-mutant locally advanced or metastatic solid tumours, non-small cell lung cancer and oesophageal and gastric cancers. ClinicalTrials.gov registers it in one study linked below. First-in-human phase 1 recruiting (NCT07284186). Whether it works in people has not been established unless a trial below reports it.
An oral SMARCA2-selective degrader that uses a tissue-restricted E3 ligase; tumours that have lost SMARCA4 depend on SMARCA2, so removing it is synthetically lethal for them. Connects to SMARCA2.
1.PLX-61639 binds SMARCA2 with one end and an E3 ubiquitin ligase with the other.
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Query for this drug: (TITLE:"PLX-61639" OR ABSTRACT:"PLX-61639") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PLX-61639, not a curated reading list.
Shares Plexium, Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares Plexium, Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares Gastric & gastro-oesophageal junction cancer, Metastatic cancer (cancer that has spread), Non-small-cell lung cancer and the tag pipeline.
Shares Gastric & gastro-oesophageal junction cancer, Non-small-cell lung cancer and the tag pipeline.
Shares Gastric & gastro-oesophageal junction cancer, Non-small-cell lung cancer and the tag pipeline.
Shares Gastric & gastro-oesophageal junction cancer, Metastatic cancer (cancer that has spread), Non-small-cell lung cancer and the tag pipeline.
Shares Gastric & gastro-oesophageal junction cancer, Non-small-cell lung cancer and the tag pipeline.
Shares Metastatic cancer (cancer that has spread), Non-small-cell lung cancer and the tag pipeline.
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