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PLX-66140 is an experimental oral molecular glue degrader from Plexium, in preclinical development for ER-positive/HER2-negative breast cancer and CCNE1-amplified tumours.
PLX-66140 is an oral molecular glue degrader (cereblon) from Plexium. A cereblon-based molecular glue that degrades CDK2, aimed at tumours driven by cyclin E (CCNE1) amplification or overexpression. Its furthest stage is preclinical development, for ER-positive/HER2-negative breast cancer and CCNE1-amplified tumours. No clinical trial naming it is registered on ClinicalTrials.gov. Preclinical on company pipeline chart. It has not been shown to work in people.
A cereblon-based molecular glue that degrades CDK2, aimed at tumours driven by cyclin E (CCNE1) amplification or overexpression. Connects to CDK2.
1.PLX-66140 binds CDK2 with one end and an E3 ubiquitin ligase with the other.
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Query for this drug: (TITLE:"PLX-66140" OR ABSTRACT:"PLX-66140") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PLX-66140, not a curated reading list.
Shares Plexium, Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares CDK2, Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares CDK2, Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares CDK2, Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares Plexium, Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares Plexium, Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares Metastatic cancer (cancer that has spread) and the tag pipeline.
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