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ETX-197 is an experimental small molecule from Ensem Therapeutics, in preclinical development for solid tumours with cyclin E amplification.
ETX-197 is a small molecule (oral) from Ensem Therapeutics. An oral CDK2 inhibitor, which the company believes could treat tumours with cyclin E amplification and cancers that have become resistant to standard treatment through CDK2 dysregulation. Its furthest stage is preclinical development, for solid tumours with cyclin E amplification. No clinical trial naming it is registered on ClinicalTrials.gov. No ClinicalTrials.gov record for ETX-197. The pipeline chart's stage is graphical only (bar not readable as text); 'preclinical' follows OnCo's text and the absence of a registered trial, not a stated source. It has not been shown to work in people.
An oral CDK2 inhibitor, which the company believes could treat tumours with cyclin E amplification and cancers that have become resistant to standard treatment through CDK2 dysregulation. Connects to CDK2.
1.ETX-197 slips into a pocket on CDK2.
Background: ADC sequencing, Antigen escape (antigen loss, lineage switch), BCG-unresponsive, Castration-resistant prostate cancer (CRPC), Circulating tumour DNA (ctDNA). Also on OnCo: Resistance: how tumours escape each drug class · Lines of therapy.
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Query for this drug: (TITLE:"ETX-197" OR ABSTRACT:"ETX-197") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ETX-197, not a curated reading list.
Shares CDK2, Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares CDK2, Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares CDK2, Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares Ensem Therapeutics, Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares Ensem Therapeutics and the tag pipeline.
Shares Ensem Therapeutics, Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares Ensem Therapeutics and the tag pipeline.
Shares Metastatic cancer (cancer that has spread) and the tag pipeline.
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