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ST-01156 is an experimental oral small-molecule molecular glue degrader from SEED Therapeutics, in phase 1 trials for ewing sarcoma, hepatocellular carcinoma and biliary tract cancer and other cancers.
ST-01156 is an oral small-molecule molecular glue degrader from SEED Therapeutics. An orally given, brain-penetrant small-molecule degrader of RBM39 that brings RBM39 together with the E3 ligase DCAF15, designed to remove oncogenic RNA-splicing dependencies across tumour types. Its furthest stage is phase 1, for ewing sarcoma, hepatocellular carcinoma, biliary tract cancer and advanced solid tumours. ClinicalTrials.gov registers it in one study linked below. Phase 1/1b NCT07197554 recruiting; company milestone '1Q 2027: Phase 1a Data'. Whether it works in people has not been established unless a trial below reports it.
An orally given, brain-penetrant small-molecule degrader of RBM39 that brings RBM39 together with the E3 ligase DCAF15, designed to remove oncogenic RNA-splicing dependencies across tumour types. Connects to RBM39.
1.ST-01156 binds RBM39 with one end and an E3 ubiquitin ligase with the other.
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Query for this drug: (TITLE:"ST-01156" OR ABSTRACT:"ST-01156") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ST-01156, not a curated reading list.
Shares RBM39, Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares Hepatocellular carcinoma, Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares Hepatocellular carcinoma, Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares Hepatocellular carcinoma, Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares Hepatocellular carcinoma, Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares Hepatocellular carcinoma, Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares Hepatocellular carcinoma, Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares Hepatocellular carcinoma, Metastatic cancer (cancer that has spread) and the tag pipeline.
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