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TLN-121 is an experimental protein degrader from Treeline Biosciences, in phase 1 trials for B-cell lymphoma, T-cell lymphoma and non-Hodgkin lymphoma.
TLN-121 is a protein degrader (small molecule) from Treeline Biosciences. Designed to remove the protein BCL6, which some lymphoma cells use to switch off genes, while avoiding off-target effects. Its furthest stage is phase 1, for B-cell lymphoma, T-cell lymphoma and non-Hodgkin lymphoma. ClinicalTrials.gov registers it in one study linked below. Registry NCT07082803 phase 1 recruiting, alone and with zeprumetostat (TLN-254). Whether it works in people has not been established unless a trial below reports it.
Designed to remove the protein BCL6, which some lymphoma cells use to switch off genes, while avoiding off-target effects. Connects to BCL6.
1.TLN-121 binds BCL6 with one end and an E3 ubiquitin ligase with the other.
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Query for this drug: (TITLE:"TLN-121" OR ABSTRACT:"TLN-121") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TLN-121, not a curated reading list.
Shares Treeline Biosciences, Non-Hodgkin lymphoma (all types) and the tag pipeline.
Shares TLN-121 in Relapsed or Refractory Non-Hodgkin Lymphomas, Treeline Biosciences and the tag pipeline.
Shares Treeline Biosciences and the tag pipeline.
Shares Treeline Biosciences and the tag pipeline.
Shares Non-Hodgkin lymphoma (all types) and the tag pipeline.
Shares Non-Hodgkin lymphoma (all types) and the tag pipeline.
Shares Non-Hodgkin lymphoma (all types) and the tag pipeline.
Shares Non-Hodgkin lymphoma (all types) and the tag pipeline.
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