Set each woman's mammogram interval from her last mammogram, using AI risk
Instead of every woman every two or three years, an AI reading of the current mammogram would set who comes back in one year and who can safely wait four.
Image-based risk models (Mirai and commercial density-plus-AI scores) outperform Tyrer-Cuzick for five-year risk. MyPeBS and WISDOM test risk-based intervals using classical risk plus polygenic scores. Propose a national programme trial where the AI score on the index mammogram assigns one-, three-, or four-year recall, with interval cancer rate and advanced-cancer incidence as endpoints.
- Most lethal cancers are found late · Screening exists for only a few cancers. Pancreatic, ovarian, liver, oesophageal and most lung cancers are found when cure is unlikely.
- Overdiagnosis and false alarms · Finding more cancer is not the same as saving lives. Screening also finds cancers that would never have hurt anyone, and treats them.
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