A therapeutic vaccine to clear cervical precancer without surgery
Precancer is treated by cutting away part of the cervix, which raises pregnancy risks. A vaccine that makes the immune system clear the infected cells would avoid surgery.
DNA vaccines such as VGX-3100 showed roughly 20-30 percentage points higher regression of CIN2/3 than placebo. Propose next-generation therapeutic vaccines (mRNA or E6/E7-targeted) tested with CIN2/3 regression plus HPV clearance as endpoints, aimed first at women planning pregnancy.
- Prevention we already have is not deployed · Around four in ten cancers are preventable with tools we already own: vaccines, tobacco control, weight, alcohol, sun and infection control.
- Overdiagnosis and false alarms · Finding more cancer is not the same as saving lives. Screening also finds cancers that would never have hurt anyone, and treats them.
Pages like this
not linked directly; found by shared links- IdeaOffer HPV vaccination to women when they come for cervical screening or treatment
Shares HPV & HBV vaccination, Prevention we already have is not deployed, Cervical cancer.
- IdeaHPV self-testing with same-day treatment as the national cervical programme
Shares HPV & HBV vaccination, Prevention we already have is not deployed, Cervical cancer.
- IdeaCommunity-tailored HPV vaccine confidence campaigns with school-based delivery
Shares HPV & HBV vaccination, Prevention we already have is not deployed, Cervical cancer.
- IdeaEliminate infection-caused cancers: HPV, hepatitis B and C, H. pylori and EBV
Shares HPV & HBV vaccination, Prevention we already have is not deployed, Cervical cancer.
- IdeaSwitch every country to single-dose HPV vaccination and add catch-up to age 26
Shares HPV & HBV vaccination, Prevention we already have is not deployed, Cervical cancer.
- PersonJian Zhou
Shares HPV & HBV vaccination, Prevention we already have is not deployed, Cervical cancer.
- IdeaSocial impact bonds for cancer prevention, repaid from avoided treatment costs
Shares HPV & HBV vaccination, Prevention we already have is not deployed, Cervical cancer.
- InstitutionMarkey Cancer Center, University of Kentucky
Shares HPV & HBV vaccination, Prevention we already have is not deployed, Cervical cancer.