Policlinico Universitario A. Gemelli
Gemelli is Rome's Catholic university hospital and a leader in gynaecologic oncology.
Gynaecologic oncology (Scambia), radiotherapy, and gastrointestinal surgery.
- Gynaecologic oncology
Surgeon who developed the laparoscopic score for predicting whether ovarian cancer can be fully removed.
Giampaolo Tortora is a medical oncologist who directs the Gemelli comprehensive cancer centre.
Giovanni Scambia is a gynaecologic oncologist who leads research at the Gemelli hospital.
Vincenzo Valentini is a radiation oncologist known for rectal cancer chemoradiation and outcome modelling.
Women with locally advanced cervical cancer that is node-positive or stage III-IVA should now be offered pembrolizumab alongside and after chemoradiotherapy, which improves the chance of cure. The result matters most in countries where cervical cancer is common but immunotherapy access is poorest, so its global impact depends on pricing and health-system capacity. It does not apply to early-stage disease treated with surgery or to lower-risk locally advanced disease without nodal involvement.
Women with newly diagnosed advanced ovarian cancer should have their tumour tested for BRCA mutations and homologous recombination deficiency, because those who are HRD-positive gain years of additional disease control and better survival from adding olaparib to bevacizumab maintenance. Those who are HRD-negative gain nothing from olaparib in this combination and should not be exposed to its toxicity and cost. HRD testing has become a routine part of ovarian cancer care as a result.