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A study that sorted muscle-invasive bladder cancers into molecular types from gene activity and found that the basal type gained most from chemotherapy before surgery.
A single-sample genomic subtyping classifier predicted four consensus molecular subtypes with 73 per cent accuracy, and patients with basal tumours showed the most improvement in overall survival with neoadjuvant chemotherapy.
Molecular type may help choose who benefits most from chemotherapy before bladder removal.
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