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CD11b is carried by most of the myeloid immune cells, and together with CD33 it is part of how myeloid-derived suppressor cells are defined: the cells that hold back a response against a tumour.
CD11b is integrin alpha M, which pairs with CD18 to form complement receptor 3 and is expressed across neutrophils, monocytes, macrophages and natural killer cells. In oncology its importance is definitional: myeloid-derived suppressor cells have no single marker of their own and are identified by a combination that includes CD11b and CD33, which is why a page on those cells needs this one.
In plain words · CD11b is carried by most of the myeloid immune cells, and together with CD33 it is part of how myeloid-derived suppressor cells are defined: the cells that hold back a response against a tumour.
CD11b is carried by most of the myeloid immune cells, and together with CD33 it is part of how myeloid-derived suppressor cells are defined: the cells that hold back a response against a tumour.
Integrin alpha M, partner of CD18 in complement receptor 3; broadly expressed across the myeloid line.
No product in this corpus aims at CD11b yet. Because it sits on the outside of the cell, it can be reached from the bloodstream: antibodies flag the cell, ADCs deliver a toxin, radioligands deliver radiation, and CAR-T or bispecifics bring a T cell.
Integrin alpha M, partner of CD18 in complement receptor 3; broadly expressed across the myeloid line.
Query for this target: (TITLE:"CD11b" OR ABSTRACT:"CD11b" OR TITLE:"ITGAM" OR ABSTRACT:"ITGAM" OR TITLE:"integrin alpha M" OR ABSTRACT:"integrin alpha M" OR TITLE:"Mac-1" OR ABSTRACT:"Mac-1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CD11b, not a curated reading list.
Shares Myeloid-derived suppressor cells (MDSCs) and the tag immune-marker.
Shares Tumour microenvironment (TME) and the tag immune-marker.
Shares Myeloid-derived suppressor cells (MDSCs), Tumour microenvironment (TME).
Shares Myeloid-derived suppressor cells (MDSCs), Tumour microenvironment (TME).
Shares Myeloid-derived suppressor cells (MDSCs), Tumour microenvironment (TME).
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