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CD66b marks neutrophils, and specifically neutrophils that have been activated. It is the marker used to pick out the granulocyte-like suppressor cells that accumulate in people with advanced cancer.
CD66b is a granulocyte activation antigen of the carcinoembryonic antigen family, held in secondary granules and brought to the cell surface when a neutrophil is activated. In cancer it is the marker used to identify the granulocytic or polymorphonuclear form of myeloid-derived suppressor cells, the population that expands in advanced disease and suppresses T cell responses. It belongs to the same family as CEACAM5, which this site records as a drug target.
In plain words · CD66b marks neutrophils, and specifically neutrophils that have been activated. It is the marker used to pick out the granulocyte-like suppressor cells that accumulate in people with advanced cancer.
CD66b marks neutrophils, and specifically neutrophils that have been activated. It is the marker used to pick out the granulocyte-like suppressor cells that accumulate in people with advanced cancer.
Granulocyte activation antigen of the CEA family, stored in secondary granules and brought to the surface on activation.
No product in this corpus aims at CD66b yet. Because it sits on the outside of the cell, it can be reached from the bloodstream: antibodies flag the cell, ADCs deliver a toxin, radioligands deliver radiation, and CAR-T or bispecifics bring a T cell.
Granulocyte activation antigen of the CEA family, stored in secondary granules and brought to the surface on activation.
Query for this target: (TITLE:"CD66b" OR ABSTRACT:"CD66b" OR TITLE:"CEACAM8" OR ABSTRACT:"CEACAM8" OR TITLE:"CGM6" OR ABSTRACT:"CGM6") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CD66b, not a curated reading list.
Shares Myeloid-derived suppressor cells (MDSCs) and the tag immune-marker.
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