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CD141 marks the rare dendritic cells that are best at showing tumour material to killer T cells. The same protein, under its other name thrombomodulin, is part of how blood clotting is kept in check.
CD141 is thrombomodulin, a cofactor that lets thrombin activate protein C and so restrains clotting on the vessel wall. In immunology it is the marker of conventional type 1 dendritic cells, the scarce subset specialised in cross-presentation, which is the route by which material taken from a dying tumour cell is shown to cytotoxic T cells. The dual identity is worth keeping in mind when reading a result: the same antibody stains endothelium.
In plain words · CD141 marks the rare dendritic cells that are best at showing tumour material to killer T cells. The same protein, under its other name thrombomodulin, is part of how blood clotting is kept in check.
CD141 marks the rare dendritic cells that are best at showing tumour material to killer T cells. The same protein, under its other name thrombomodulin, is part of how blood clotting is kept in check.
Thrombomodulin, an endothelial anticoagulant cofactor, which also marks the cross-presenting cDC1 dendritic subset.
No product in this corpus aims at CD141 yet. Because it sits on the outside of the cell, it can be reached from the bloodstream: antibodies flag the cell, ADCs deliver a toxin, radioligands deliver radiation, and CAR-T or bispecifics bring a T cell.
Thrombomodulin, an endothelial anticoagulant cofactor, which also marks the cross-presenting cDC1 dendritic subset.
Query for this target: (TITLE:"CD141" OR ABSTRACT:"CD141" OR TITLE:"THBD" OR ABSTRACT:"THBD" OR TITLE:"thrombomodulin" OR ABSTRACT:"thrombomodulin" OR TITLE:"BDCA-3" OR ABSTRACT:"BDCA-3") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CD141, not a curated reading list.
Shares CD11c, Antigen presentation & immune editing and the tag immune-marker.
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