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HLA-DR is the display case that antigen-presenting cells use to show fragments to helper T cells. When monocytes lose it, the immune system is suppressed, which happens in advanced cancer and severe illness.
HLA-DR is an MHC class II molecule, the structure on which antigen-presenting cells display peptide to CD4 helper T cells, and the alpha chain HLA-DRA is the gene given here. Two uses matter in oncology. It is part of how dendritic cells, B cells and monocytes are identified in a panel; and low HLA-DR on monocytes is a recognised sign of immune suppression, used as a marker of the suppressed myeloid state seen in advanced cancer and critical illness. Myeloid-derived suppressor cells are defined partly by that absence.
In plain words · HLA-DR is the display case that antigen-presenting cells use to show fragments to helper T cells. When monocytes lose it, the immune system is suppressed, which happens in advanced cancer and severe illness.
HLA-DR is the display case that antigen-presenting cells use to show fragments to helper T cells. When monocytes lose it, the immune system is suppressed, which happens in advanced cancer and severe illness.
MHC class II molecule presenting peptide to CD4 T cells; the alpha chain HLA-DRA is given here.
No product in this corpus aims at HLA-DR yet. Because it sits on the outside of the cell, it can be reached from the bloodstream: antibodies flag the cell, ADCs deliver a toxin, radioligands deliver radiation, and CAR-T or bispecifics bring a T cell.
MHC class II molecule presenting peptide to CD4 T cells; the alpha chain HLA-DRA is given here.
Query for this target: (TITLE:"HLA-DR" OR ABSTRACT:"HLA-DR" OR TITLE:"HLA-DRA" OR ABSTRACT:"HLA-DRA" OR TITLE:"MHC class II DR" OR ABSTRACT:"MHC class II DR") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about HLA-DR, not a curated reading list.
Shares CD11c, Antigen presentation & immune editing and the tag immune-marker.
Shares CD11c, Antigen presentation & immune editing and the tag immune-marker.
Shares CD4 and the tag immune-marker.
Shares CD4 and the tag immune-marker.
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