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CXCR5 is what draws immune cells into the follicles where B cells are trained. The same signal builds the lymph-node-like structures that sometimes form inside tumours and are linked to better outcomes.
CXCR5 binds CXCL13 and is the receptor that organises cells into B cell follicles, carried by B cells and by the follicular helper T cells that support them. Its relevance to cancer is through tertiary lymphoid structures, the organised immune aggregates that form within some tumours and are associated with response to checkpoint blockade; CXCL13 and CXCR5 are part of how those structures assemble.
In plain words · CXCR5 is what draws immune cells into the follicles where B cells are trained. The same signal builds the lymph-node-like structures that sometimes form inside tumours and are linked to better outcomes.
CXCR5 is what draws immune cells into the follicles where B cells are trained. The same signal builds the lymph-node-like structures that sometimes form inside tumours and are linked to better outcomes.
Receptor for CXCL13; directs cells into B cell follicles and germinal centres.
No product in this corpus aims at CXCR5 yet. Because it sits on the outside of the cell, it can be reached from the bloodstream: antibodies flag the cell, ADCs deliver a toxin, radioligands deliver radiation, and CAR-T or bispecifics bring a T cell.
Receptor for CXCL13; directs cells into B cell follicles and germinal centres.
Query for this target: (TITLE:"CXCR5" OR ABSTRACT:"CXCR5") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CXCR5, not a curated reading list.
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