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Tertiary lymphoid structures are organised clusters of immune cells that form inside tumours and resemble small lymph nodes; their presence is linked to better immunotherapy outcomes.
Sautès-Fridman and colleagues review tertiary lymphoid structures as organised aggregates of B cells, T cells and dendritic cells that develop in chronically inflamed tissues including tumours, where they are generally associated with longer survival and response to checkpoint inhibitors. Because they are visible on H&E and spatial assays, they are a known-biology probe: a slide or spatial model that recovers TLS is learning something real.
Showing the technology this term belongs to: Spatial transcriptomics.
Shares Mechanism-of-action recovery and known-biology probes, Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.
Shares Spatial transcriptomics, Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.
Shares Spatial transcriptomics, Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.
Shares Mechanism-of-action recovery and known-biology probes, Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.
Shares Microenvironment and inflammation: tumours as wounds that do not heal, Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.
Shares Spatial transcriptomics, Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.
Shares Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.
Shares Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.