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Because a tumour sample is a mix of cancer, stromal and immune cells, a difference between two samples may only reflect a different mix of cells.
The tumour microenvironment, as Wikipedia describes it, is the ecosystem of cancer cells, stromal tissue, immune cells and extracellular matrix around a tumour. Any measurement on the whole sample (bulk expression, methylation, a region of a spatial section) averages over that mix, so an apparent risk or subtype difference between regions or patients can be a composition difference rather than a change in the cancer cells themselves. Deconvolution and purity estimates are the usual corrections.
Shares Tumour purity, Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.
Shares Microenvironment and inflammation: tumours as wounds that do not heal, Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.
Shares Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.
Shares Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.
Shares Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.
Shares Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.
Shares Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.
Shares Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.