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Tumour purity is the fraction of cells in a sample that are actually cancer cells rather than normal, immune or stromal cells.
Aran, Sirota and Butte's pan-cancer analysis of TCGA estimated the proportion of cancer cells in each sample by several methods (pathologist counts, copy number, expression and methylation based estimators) and showed purity varies widely between and within cancer types and confounds molecular comparisons. Bulk sequencing measures the whole mixture, so a low-purity sample can look like a different tumour; models trained on bulk data inherit this.
Shares Bulk RNA sequencing (RNA-seq) and the full transcriptome, Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.
Shares Bulk RNA sequencing (RNA-seq) and the full transcriptome, Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.
Shares Bulk RNA sequencing (RNA-seq) and the full transcriptome, Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.
Shares Bulk RNA sequencing (RNA-seq) and the full transcriptome, Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.
Shares Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.
Shares Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.
Shares Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.
Shares Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.