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CD11c identifies dendritic cells, the cells that carry pieces of a tumour to the lymph node and show them to T cells. Without that step, a T cell never learns the cancer is there.
CD11c is integrin alpha X and the conventional marker of dendritic cells, the professional antigen-presenting cells that take material from a tumour to a draining lymph node and present it to T cells. It is not exclusive to them, appearing on macrophages and some B cells, which is why dendritic subsets are defined by CD11c together with CD1c and CD141. Antigen presentation is the step every immunotherapy depends on, so this is a marker for the beginning of the response rather than its end.
In plain words · CD11c identifies dendritic cells, the cells that carry pieces of a tumour to the lymph node and show them to T cells. Without that step, a T cell never learns the cancer is there.
CD11c identifies dendritic cells, the cells that carry pieces of a tumour to the lymph node and show them to T cells. Without that step, a T cell never learns the cancer is there.
Integrin alpha X, partner of CD18; the conventional marker of dendritic cells.
No product in this corpus aims at CD11c yet. Because it sits on the outside of the cell, it can be reached from the bloodstream: antibodies flag the cell, ADCs deliver a toxin, radioligands deliver radiation, and CAR-T or bispecifics bring a T cell.
Integrin alpha X, partner of CD18; the conventional marker of dendritic cells.
Query for this target: (TITLE:"CD11c" OR ABSTRACT:"CD11c" OR TITLE:"ITGAX" OR ABSTRACT:"ITGAX" OR TITLE:"integrin alpha X" OR ABSTRACT:"integrin alpha X") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CD11c, not a curated reading list.
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