DDX41
DDX41 (Probable ATP-dependent RNA helicase DDX41) is an enzyme. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Leukaemia, Myeloproliferative neoplasms, Myelodysplastic syndromes / neoplasms and 1 more.
Overview
Multifunctional protein that participates in many aspects of cellular RNA metabolism. Plays pivotal roles in innate immune sensing and haematopoietic homeostasis. Recognises foreign or self-nucleic acids generated during microbial infection, thereby initiating anti-pathogen responses.
CIViC holds 11 clinical evidence items and 1 assertion across 4 variants. Open Targets scores its association with cancer at 0.77 (direct and indirect evidence; datatypes literature 0.93, genetic association 0.94, genetic literature 0.76).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · DDX41 (Probable ATP-dependent RNA helicase DDX41) is an enzyme. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Leukaemia, Myeloproliferative neoplasms, Myelodysplastic syndromes / neoplasms and 1 more.
- 1 · What it is
DDX41 (Probable ATP-dependent RNA helicase DDX41) is an enzyme. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Leukaemia, Myeloproliferative neoplasms, Myelodysplastic syndromes / neoplasms and 1 more.
- 2 · What goes wrong in cancer
Multifunctional protein that participates in many aspects of cellular RNA metabolism. Plays pivotal roles in innate immune sensing and haematopoietic homeostasis.
- 3 · How drugs use it
No product in this corpus aims at DDX41 yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
External identifiers
Sources: HGNC HGNC:18674 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9UJV9 (protein name, function text, keywords and locations (REST API)); CIViC gene DDX41 (11 evidence items, 1 assertions, 4 variants; diseases: Myeloid Neoplasm, Acute Myeloid Leukaemia, Myelodysplastic Syndrome, Haematologic Cancer (GraphQL API, CC0)); Open Targets ENSG00000183258 (association with cancer (MONDO_0004992) 0.77; per-cancer scores at or above 0.5: acute myeloid leukaemia 0.72, myelodysplastic syndrome 0.69, myeloproliferative neoplasm 0.77, leukaemia 0.77 (GraphQL API, CC0))
Biology
Multifunctional protein that participates in many aspects of cellular RNA metabolism. Plays pivotal roles in innate immune sensing and haematopoietic homeostasis. Recognises foreign or self-nucleic acids generated during microbial infection, thereby initiating anti-pathogen responses. Mechanistically, phosphorylation by BTK allows binding to dsDNA leading to interaction with STING1. Modulates the homeostasis of dsDNA through its ATP-dependent DNA-unwinding activity and ATP-independent strand-annealing activity. In turn, induces STING1-mediated type I interferon and cytokine responses to DNA and DNA viruses. Location: Nucleus; Cytoplasm (UniProt). Locus 5q35.3 (HGNC).
- Leukaemia: Open Targets association 0.77 with leukaemia (MONDO_0005059)
- Myeloproliferative neoplasms: Open Targets association 0.77 with myeloproliferative neoplasm (MONDO_0020076)
- Myelodysplastic syndromes / neoplasms: Open Targets association 0.69 with myelodysplastic syndrome (MONDO_0018881); CIViC evidence names this disease
- Acute myeloid leukaemia: Open Targets association 0.72 with acute myeloid leukaemia (MONDO_0018874); CIViC evidence names this disease
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 11 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
- Diseases the sources name that have no OnCo cancer page yet, so they are not linked: Myeloid Neoplasm; Haematologic Cancer.
Latest papers
topQuery for this target: (TITLE:"DDX41" OR ABSTRACT:"DDX41" OR TITLE:"DEAD-box helicase 41" OR ABSTRACT:"DEAD-box helicase 41" OR TITLE:"Probable ATP-dependent RNA helicase DDX41" OR ABSTRACT:"Probable ATP-dependent RNA helicase DDX41" OR TITLE:"MGC8828" OR ABSTRACT:"MGC8828") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about DDX41, not a curated reading list.
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