EPHA10
EPHA10 (Ephrin type-A receptor 10) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Thyroid cancer and Neuroendocrine tumours.
Overview
Receptor for members of the ephrin-A family. Binds to EFNA3, EFNA4 and EFNA5.
Open Targets scores its association with cancer at 0.60 (direct and indirect evidence; datatypes literature 0.93, genetic association 0.03, clinical 0.93).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · EPHA10 (Ephrin type-A receptor 10) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Thyroid cancer and Neuroendocrine tumours.
- 1 · What it is
EPHA10 (Ephrin type-A receptor 10) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Thyroid cancer and Neuroendocrine tumours.
- 2 · What goes wrong in cancer
Receptor for members of the ephrin-A family. Binds to EFNA3, EFNA4 and EFNA5.
- 3 · How drugs use it
No product in this corpus aims at EPHA10 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:19987 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q5JZY3 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000183317 (association with cancer (MONDO_0004992) 0.60; per-cancer scores at or above 0.5: thyroid cancer 0.56, neuroendocrine neoplasm 0.54 (GraphQL API, CC0))
Biology
Receptor for members of the ephrin-A family. Binds to EFNA3, EFNA4 and EFNA5. Location: Cell membrane; Secreted (UniProt). Locus 1p34.3 (HGNC).
- Thyroid cancer: Open Targets association 0.56 with thyroid cancer (MONDO_0002108)
- Neuroendocrine tumours: Open Targets association 0.54 with neuroendocrine neoplasm (MONDO_0019496)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.93. Evidence tier "approved-drug" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"EPHA10" OR ABSTRACT:"EPHA10" OR TITLE:"EPH receptor A10" OR ABSTRACT:"EPH receptor A10" OR TITLE:"Ephrin type-A receptor 10" OR ABSTRACT:"Ephrin type-A receptor 10" OR TITLE:"FLJ16103" OR ABSTRACT:"FLJ16103" OR TITLE:"FLJ33655" OR ABSTRACT:"FLJ33655") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about EPHA10, not a curated reading list.
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