KAT2A
KAT2A (Histone acetyltransferase KAT2A) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
Overview
Protein lysine acyltransferase that catalyses acetylation of histone and non-histone proteins using acetyl-CoA. Also catalyses acyl-CoA-dependent acylation of lysine residues in proteins using alternative acyl-CoA donors, including propionyl-CoA, butyryl-CoA, succinyl-CoA, glutaryl-CoA, crotonyl-CoA and lactoyl-CoA. Acts as a histone lysine succinyltransferase: catalyses succinylation of histone H3 on 'Lys-79' (H3K79succ), with a maximum frequency around the transcription start sites of genes.
Open Targets scores its association with cancer at 0.63 (direct and indirect evidence; datatypes literature 0.95, affected pathway 0.80, animal model 0.30, genetic association 0.00).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · KAT2A (Histone acetyltransferase KAT2A) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
- 1 · What it is
KAT2A (Histone acetyltransferase KAT2A) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
- 2 · What goes wrong in cancer
Protein lysine acyltransferase that catalyses acetylation of histone and non-histone proteins using acetyl-CoA.
- 3 · How drugs use it
No product in this corpus aims at KAT2A yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
External identifiers
Sources: HGNC HGNC:4201 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q92830 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000108773 (association with cancer (MONDO_0004992) 0.63; (GraphQL API, CC0))
Biology
Protein lysine acyltransferase that catalyses acetylation of histone and non-histone proteins using acetyl-CoA. Also catalyses acyl-CoA-dependent acylation of lysine residues in proteins using alternative acyl-CoA donors, including propionyl-CoA, butyryl-CoA, succinyl-CoA, glutaryl-CoA, crotonyl-CoA and lactoyl-CoA. Acts as a histone lysine succinyltransferase: catalyses succinylation of histone H3 on 'Lys-79' (H3K79succ), with a maximum frequency around the transcription start sites of genes. Succinylation of histones gives a specific tag for epigenetic transcription activation. Association with the 2-oxoglutarate dehydrogenase complex, which provides succinyl-CoA, is required for histone succinylation. In different complexes, functions either as an acetyltransferase (HAT) or as a succinyltransferase: in the SAGA and ATAC complexes, acts as a histone acetyltransferase. Location: Nucleus; Chromosome; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome (UniProt). Locus 17q21.2 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"KAT2A" OR ABSTRACT:"KAT2A" OR TITLE:"lysine acetyltransferase 2A" OR ABSTRACT:"lysine acetyltransferase 2A" OR TITLE:"Histone acetyltransferase KAT2A" OR ABSTRACT:"Histone acetyltransferase KAT2A" OR TITLE:"GCN5" OR ABSTRACT:"GCN5" OR TITLE:"PCAF-b" OR ABSTRACT:"PCAF-b" OR TITLE:"GCN5L2" OR ABSTRACT:"GCN5L2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about KAT2A, not a curated reading list.