PRKDC
PRKDC (DNA-dependent protein kinase catalytic subunit) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as a drug target, a biomarker and a DNA repair gene, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Melanoma, Non-small-cell lung cancer and Diffuse large B-cell lymphoma.
Overview
Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. Must be bound to DNA to express its catalytic properties.
CIViC holds 3 clinical evidence items and 0 assertions across 1 variant, naming Anti-CTLA-4 Monoclonal Antibody and Anti-PD1 Monoclonal Antibody.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · PRKDC (DNA-dependent protein kinase catalytic subunit) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as a drug target, a biomarker and a DNA repair gene, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Melanoma, Non-small-cell lung cancer and Diffuse large B-cell lymphoma.
- 1 · What it is
PRKDC (DNA-dependent protein kinase catalytic subunit) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as a drug target, a biomarker and a DNA repair gene, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Melanoma, Non-small-cell lung cancer and Diffuse large B-cell lymphoma.
- 2 · What goes wrong in cancer
Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination.
- 3 · How drugs use it
No product in this corpus aims at PRKDC yet. Kinases are switched on by binding ATP inside the cell, so most drugs are small molecules shaped to plug that ATP pocket.
External identifiers
Sources: HGNC HGNC:9413 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P78527 (protein name, function text, keywords and locations (REST API)); CIViC gene PRKDC (3 evidence items, 0 assertions, 1 variants; diseases: Melanoma, Lung Non-small Cell Carcinoma, Diffuse Large B-cell Lymphoma (GraphQL API, CC0))
Biology
Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. Must be bound to DNA to express its catalytic properties. Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C). Recruited by XRCC5 and XRCC6 to DNA ends and is required to (1) protect and align broken ends of DNA, thereby preventing their degradation, (2) and sequester the DSB for repair by NHEJ. Acts as a scaffold protein to aid the localisation of DNA repair proteins to the site of damage. Location: Nucleus; Nucleus, nucleolus; Cytoplasm, cytosol (UniProt). Locus 8q11.21 (HGNC).
- Melanoma: CIViC evidence names this disease
- Non-small-cell lung cancer: CIViC evidence names this disease
- Diffuse large B-cell lymphoma: CIViC evidence names this disease
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 2 therapies; CIViC holds 3 clinical evidence items on its variants; UniProt keyword "DNA repair". Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"PRKDC" OR ABSTRACT:"PRKDC" OR TITLE:"protein kinase, DNA-activated, catalytic subunit" OR ABSTRACT:"protein kinase, DNA-activated, catalytic subunit" OR TITLE:"DNA-dependent protein kinase catalytic subunit" OR ABSTRACT:"DNA-dependent protein kinase catalytic subunit" OR TITLE:"DNPK1" OR ABSTRACT:"DNPK1" OR TITLE:"p350" OR ABSTRACT:"p350" OR TITLE:"DNAPK" OR ABSTRACT:"DNAPK") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PRKDC, not a curated reading list.