TYK2
TYK2 (Non-receptor tyrosine-protein kinase TYK2) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as a drug target and a biomarker, and an approved or late-stage drug is recorded against it. Tied to Myeloproliferative neoplasms, Malignant peripheral nerve sheath tumour and Polycythaemia vera.
Overview
Non-membrane spanning protein tyrosine kinase involved in numerous cytokines and interferons signalling, which regulates cell growth, development, cell migration, innate and adaptive immunity. Plays both structural and catalytic roles in numerous interleukins and interferons (IFN-alpha/beta) signalling. Associates with heterodimeric cytokine receptor complexes and activates STAT family members including STAT1, STAT3, STAT4 or STAT6.
CIViC holds 1 clinical evidence item and 0 assertions across 2 variants. Open Targets scores its association with cancer at 0.73 (direct and indirect evidence; datatypes clinical 0.96, affected pathway 0.83, literature 0.96, genetic association 0.00, animal model 0.49).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · TYK2 (Non-receptor tyrosine-protein kinase TYK2) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as a drug target and a biomarker, and an approved or late-stage drug is recorded against it. Tied to Myeloproliferative neoplasms, Malignant peripheral nerve sheath tumour and Polycythaemia vera.
- 1 · What it is
TYK2 (Non-receptor tyrosine-protein kinase TYK2) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as a drug target and a biomarker, and an approved or late-stage drug is recorded against it. Tied to Myeloproliferative neoplasms, Malignant peripheral nerve sheath tumour and Polycythaemia vera.
- 2 · What goes wrong in cancer
Non-membrane spanning protein tyrosine kinase involved in numerous cytokines and interferons signalling, which regulates cell growth, development, cell migration, innate and adaptive immunity.
- 3 · How drugs use it
No product in this corpus aims at TYK2 yet. Kinases are switched on by binding ATP inside the cell, so most drugs are small molecules shaped to plug that ATP pocket.
External identifiers
Sources: HGNC HGNC:12440 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P29597 (protein name, function text, keywords and locations (REST API)); CIViC gene TYK2 (1 evidence items, 0 assertions, 2 variants; diseases: Malignant Peripheral Nerve Sheath Tumour (GraphQL API, CC0)); Open Targets ENSG00000105397 (association with cancer (MONDO_0004992) 0.73; per-cancer scores at or above 0.5: myeloproliferative neoplasm 0.60, acquired polycythemia vera 0.50 (GraphQL API, CC0))
Biology
Non-membrane spanning protein tyrosine kinase involved in numerous cytokines and interferons signalling, which regulates cell growth, development, cell migration, innate and adaptive immunity. Plays both structural and catalytic roles in numerous interleukins and interferons (IFN-alpha/beta) signalling. Associates with heterodimeric cytokine receptor complexes and activates STAT family members including STAT1, STAT3, STAT4 or STAT6. The heterodimeric cytokine receptor complexes are composed of (1) a TYK2-associated receptor chain (IFNAR1, IL12RB1, IL10RB or IL13RA1), and (2) a second receptor chain associated either with JAK1 or JAK2. In response to cytokine-binding to receptors, phosphorylates and activates receptors (IFNAR1, IL12RB1, IL10RB or IL13RA1), creating docking sites for STAT members. In turn, recruited STATs are phosphorylated by TYK2 (or JAK1/JAK2 on the second receptor chain), form homo- and heterodimers, translocate to the nucleus, and regulate cytokine/growth factor responsive genes. Locus 19p13.2 (HGNC).
- Myeloproliferative neoplasms: Open Targets association 0.60 with myeloproliferative neoplasm (MONDO_0020076)
- Malignant peripheral nerve sheath tumour: CIViC evidence names this disease
- Polycythaemia vera: Open Targets association 0.50 with acquired polycythemia vera (MONDO_0009891)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.96; CIViC holds 1 clinical evidence items on its variants. Evidence tier "approved-drug" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"TYK2" OR ABSTRACT:"TYK2" OR TITLE:"tyrosine kinase 2" OR ABSTRACT:"tyrosine kinase 2" OR TITLE:"Non-receptor tyrosine-protein kinase TYK2" OR ABSTRACT:"Non-receptor tyrosine-protein kinase TYK2" OR TITLE:"JTK1" OR ABSTRACT:"JTK1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TYK2, not a curated reading list.
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