AALL1521
AALL1521 is the trial that added the JAK-blocking pill ruxolitinib to chemotherapy for children whose leukaemia looks like Philadelphia-positive disease but is driven by JAK signalling; it has finished treating patients and the survival results are awaited.
Overview
AALL1521 is a single-arm phase 2 study run by Incyte with the Children's Oncology Group in children and young adults with newly diagnosed high-risk B-cell acute lymphoblastic leukaemia that is Philadelphia chromosome-like with a CRLF2 rearrangement or a JAK pathway mutation, or with other JAK-STAT activating lesions. Ruxolitinib was added to the AALL1131 high-risk chemotherapy backbone from consolidation onwards. Part 1 established the safe dose and schedule; Part 2 measures three-year event-free survival in each genetic cohort.
The study enrolled 171 patients and is recorded as completed with a primary completion date of March 2026. No primary results have been posted on the registry or published in a journal indexed by Europe PMC, so the corpus records what the trial tests and not a result. The Philadelphia-like leukaemia page cites it as the trial through which ruxolitinib is being added to chemotherapy.
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