EORTC 22922/10925
EORTC 22922 showed that irradiating the internal mammary and supraclavicular nodes reduces breast cancer recurrence and death, with a small effect on overall survival, and made regional nodal irradiation standard for node-positive disease.
Overview
EORTC 22922/10925 randomised 4,004 women with node-positive or medially located early breast cancer to whole-breast or chest wall radiotherapy with or without irradiation of the internal mammary and medial supraclavicular nodes. Ten-year overall survival was 82.3 percent with nodal irradiation and 80.7 percent without (hazard ratio 0.87, borderline), with fewer distant recurrences and breast cancer deaths (Poortmans and colleagues, New England Journal of Medicine 2015); 15-year results confirmed lower breast cancer mortality without an overall survival difference.
- 82.3 vs 80.7 out of 100 alive at 10 years with Regional nodal irradiation compared with No nodal irradiation; 1.6 more per 100.
- Roughly one extra person helped for every 63 treated. That is a rough figure taken from the two percentages, not a guarantee for any one person.
- Overall survival counts deaths from any cause, so it is the most direct measure of whether a treatment helps people live longer.
- These results apply to the people the trial enrolled: Early breast cancer with involved axillary nodes or a central or medial tumour: regional nodal irradiation (internal mammary and medial supraclavicular) added to breast or chest wall radiotherapy, versus none. People in a different situation may not see the same effect.
Numbers are from the trial as recorded here; see the source links in the table below. This is orientation, not medical advice: ask your team how closely the trial population matches you.
4,004 participants enrolled.
| Endpoint | Arm | n | Value | HR (95% CI) | p | Source |
|---|---|---|---|---|---|---|
| Overall survival at 10 yearsprimary | Regional nodal irradiation | 2,002 | 82.3% | - | - | - |
| No nodal irradiation | 2,002 | 80.7% |
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