RTOG 0617
RTOG 0617 is the trial that stopped dose escalation in lung cancer: patients given 74 Gy lived shorter than those given the standard 60 Gy, and cetuximab added nothing.
Overview
RTOG 0617 randomised 544 patients with stage III non-small-cell lung cancer receiving concurrent carboplatin-paclitaxel to 60 Gy or 74 Gy, with or without cetuximab. Median overall survival was 28.7 months with 60 Gy and 20.3 months with 74 Gy; the high-dose arm had more treatment-related deaths and higher heart dose, and cetuximab gave no benefit (Bradley and colleagues, Lancet Oncology 2015). The result fixed 60 Gy as the standard and drew attention to heart dose as a determinant of survival.
- Median 28.7 vs 20.3 months with 60 Gy compared with 74 Gy; about 8.4 months longer for half the group.
- A median is a midpoint: half the people did better than this and half did worse, so it is not a prediction for any one person.
- Overall survival counts deaths from any cause, so it is the most direct measure of whether a treatment helps people live longer.
- These results apply to the people the trial enrolled: Stage III non-small-cell lung cancer with concurrent chemotherapy: 74 Gy versus 60 Gy, with or without cetuximab. People in a different situation may not see the same effect.
Numbers are from the trial as recorded here; see the source links in the table below. This is orientation, not medical advice: ask your team how closely the trial population matches you.
544 participants enrolled.
| Endpoint | Arm | n | Value | HR (95% CI) | p | Source |
|---|---|---|---|---|---|---|
| Median overall survivalprimary | 60 Gy | 217 | 28.7 months | - | - | - |
| 74 Gy | 207 | 20.3 months |
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