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DNX-2401 is an experimental oncolytic adenovirus from DNAtrix, in phase 2 trials for recurrent glioblastoma, malignant glioma and diffuse intrinsic pontine glioma and other cancers; its current status is not stated.
DNX-2401 (DNX2401, Delta-24-RGD-4C, Ad5-DNX-2401) is an oncolytic adenovirus from DNAtrix. An engineered version of the common cold virus (adenovirus) designed to selectively infect and kill cancer cells while leaving healthy cells unharmed. Its furthest stage is phase 2, for recurrent glioblastoma, malignant glioma, diffuse intrinsic pontine glioma and paediatric high-grade brain tumours. ClinicalTrials.gov registers it in 9 studies linked below. DNAtrix said in March 2021 that DNX-2401 'will enter into a global pivotal Phase 3 clinical study' in recurrent glioblastoma; no such phase 3 is registered. DNAtrix's own studies are completed and the company has announced nothing since 2021. Investigator-sponsored trials are still recruiting (NCT07424092 Navarra phase 2, NCT05009992 UCSF phase 2, NCT03896568 and NCT07444606 MD Anderson phase 1), registry checked 3 Nov 2026. Whether it works in people has not been established unless a trial below reports it.
An engineered version of the common cold virus (adenovirus) designed to selectively infect and kill cancer cells while leaving healthy cells unharmed.
1.DNX-2401 slips into a pocket on its target.
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Query for this drug: (TITLE:"DNX-2401" OR ABSTRACT:"DNX-2401" OR TITLE:"DNX2401" OR ABSTRACT:"DNX2401" OR TITLE:"Delta-24-RGD-4C" OR ABSTRACT:"Delta-24-RGD-4C" OR TITLE:"Ad5-DNX-2401" OR ABSTRACT:"Ad5-DNX-2401") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about DNX-2401, not a curated reading list.
Shares DNAtrix, Glioma & glioblastoma, Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares Diffuse midline glioma, H3 K27-altered (including DIPG), Brain and spinal cord tumours (all types), Glioma & glioblastoma and the tag pipeline.
Shares Diffuse midline glioma, H3 K27-altered (including DIPG), Brain and spinal cord tumours (all types), Glioma & glioblastoma and the tag pipeline.
Shares DNAtrix, Melanoma, Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares DNAtrix, Glioma & glioblastoma and the tag pipeline.
Shares Brain and spinal cord tumours (all types), Melanoma, Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares Brain and spinal cord tumours (all types), Melanoma, Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares Diffuse midline glioma, H3 K27-altered (including DIPG), Glioma & glioblastoma and the tag pipeline.
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