Flutamide
Flutamide was the first tablet to block testosterone at the prostate cancer cell. It is taken with an injection that stops testosterone production, but newer drugs have largely replaced it.
Overview
Flutamide was approved in 1989 for use with LHRH agonists in stage B2 to C prostate cancer (with radiotherapy) and in stage D2 metastatic disease, introducing combined androgen blockade. Trials in the 1980s and 1990s showed at best a small survival gain over castration alone, and bicalutamide, then enzalutamide, apalutamide and darolutamide superseded it because of three-times-daily dosing, diarrhoea and a boxed warning for hepatotoxicity including fatal liver failure. It is still listed for antiandrogen flare cover at the start of LHRH agonist therapy.
Approvals
| Region | Year | Indication |
|---|---|---|
| US | 1989 | Locally advanced (B2 to C) and metastatic (D2) prostate cancer in combination with an LHRH agonist |
Trials
topRecruiting now (live from ClinicalTrials.gov)
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Latest papers
topQuery for this drug: (TITLE:"Flutamide" OR ABSTRACT:"Flutamide" OR TITLE:"Eulexin" OR ABSTRACT:"Eulexin" OR TITLE:"historic" OR ABSTRACT:"historic") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Flutamide, not a curated reading list.
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