Nilutamide
Nilutamide (Nilandron) is an older antiandrogen tablet started on the day of surgical castration for metastatic prostate cancer; it is rarely used now because of lung and eye side effects.
Overview
Nilutamide was approved in 1996 for metastatic (stage D2) prostate cancer in combination with surgical castration, with treatment beginning on the day of or the day after orchiectomy, on a randomised trial in which the combination modestly delayed progression compared with castration alone. It has been superseded by bicalutamide and the second-generation antiandrogens. Interstitial pneumonitis (about 2% of patients, more in Japanese men) carries a boxed warning; delayed dark adaptation, alcohol intolerance and hepatitis are also characteristic.
- AmivantamabApproved
- CamizestrantApproved
- Comprehensive genomic profilingStandard of care
- Liquid biopsy (ctDNA)Standard of care
- LorlatinibApproved
- MRD / molecular residual disease testingEstablished
- ADC payload neutralisersPhase 1
- BGB-16673Phase 3
- Bispecific ADCPhase 3
- BRUIN CLL-321Positive
- CaDAnCe-304Recruiting
- CIRCULATE-Japan (GALAXY / VEGA / ALTAIR)Active
- A clone report from blood at every treatment cycle
- A fast route to the matched drug when it is licensed for another cancer
- A multi-cancer platform trial of adaptive (dose-holiday) therapy
- A national rapid research autopsy network for end-stage cancer
- A standard evolvability score for every tumour
- A standing platform trial that assigns treatment by how the tumour escaped
Background: ADC sequencing, Antigen escape (antigen loss, lineage switch), BCG-unresponsive, Castration-resistant prostate cancer (CRPC), Circulating tumour DNA (ctDNA). Also on OnCo: Resistance atlas: how tumours escape and what closes the route · Lines of therapy.
Approvals
| Region | Year | Indication |
|---|---|---|
| US | 1996 | Metastatic (stage D2) prostate cancer in combination with surgical castration |
Trials
topRecruiting now (live from ClinicalTrials.gov)
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Latest papers
topQuery for this drug: (TITLE:"Nilutamide" OR ABSTRACT:"Nilutamide" OR TITLE:"Nilandron" OR ABSTRACT:"Nilandron" OR TITLE:"Anandron" OR ABSTRACT:"Anandron") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Nilutamide, not a curated reading list.
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