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A urine test that reads 18 prostate cancer genes to estimate the chance of a cancer worth treating, to help decide on a biopsy.
Medicare's code 0403U describes "MRNA, GENE EXPRESSION PROFILING OF 18 GENES, FIRST-CATCH URINE", and Palmetto MolDX article A58700 lists it for the pre-biopsy and post-biopsy settings. In its development and validation study (validation cohort 743), the area under the curve for grade group 2 or higher cancer was 0.81 for MPS2 and 0.82 for MPS2+, against 0.60 for PSA alone and 0.77 for the Prostate Health Index, with negative predictive values of 95 to 99 per cent (Tosoian 2024). The maker's site refused the request, so its current owner and claims are not recorded here.
Expression of 18 genes in first-catch urine is combined with clinical factors into a probability of clinically significant prostate cancer.
| Country | Reimbursement | List price | Assistance |
|---|---|---|---|
| United States | Medicare (Palmetto MolDX billing article A58700) lists MyProstateScore 2.0 for men at increased risk of prostate cancer, before and after biopsy | not disclosed | - |
List prices are manufacturer or Medicare figures where publicly disclosed; net prices after rebates are usually lower. Reimbursement changes; check the payer.
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Query for this drug: (TITLE:"MyProstateScore 2.0" OR ABSTRACT:"MyProstateScore 2.0" OR TITLE:"MPS2" OR ABSTRACT:"MPS2" OR TITLE:"MyProstateScore" OR ABSTRACT:"MyProstateScore" OR TITLE:"MPS 2.0" OR ABSTRACT:"MPS 2.0" OR TITLE:"18-gene urine test" OR ABSTRACT:"18-gene urine test") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about MyProstateScore 2.0, not a curated reading list.
Shares ExoDx Prostate (IntelliScore), Liquid RNA biopsy (cell-free, vesicle and platelet RNA), Prostate cancer and the tags test, rna.
Shares ExoDx Prostate (IntelliScore), Liquid RNA biopsy (cell-free, vesicle and platelet RNA), Prostate cancer and the tags test, rna.
Shares Liquid RNA biopsy (cell-free, vesicle and platelet RNA) and the tags test, rna.
Shares the tags test, rna.
Shares the tags test, rna.
Shares the tags test, rna.
Shares the tags test, rna.
Shares the tags test, rna.
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