Nedaplatin
Nedaplatin is a Japanese platinum drug, approved there in 1995, used for head and neck, oesophageal, lung, cervical and other squamous cancers as a gentler alternative to cisplatin on the kidneys; it has never been approved in the West.
Overview
Shionogi developed nedaplatin to keep cisplatin's activity while reducing kidney damage and vomiting. Japan approved it in 1995 for head and neck, testicular, lung, oesophageal, ovarian and cervical cancers, and China followed. Randomised trials in Japan and China have shown it comparable to cisplatin with radiotherapy in nasopharyngeal and cervical cancer and in squamous non-small cell lung cancer with docetaxel, with less nephrotoxicity but more thrombocytopenia. It is not approved in the United States or Europe, where carboplatin fills the role of the better tolerated platinum.
A platinum complex that forms DNA cross-links like cisplatin but with a glycolate leaving group that makes it less nephrotoxic and emetogenic.
1.Nedaplatin slips into a pocket on its target.
Trials
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Latest papers
topQuery for this drug: (TITLE:"Nedaplatin" OR ABSTRACT:"Nedaplatin" OR TITLE:"Aqupla" OR ABSTRACT:"Aqupla" OR TITLE:"254-S" OR ABSTRACT:"254-S") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Nedaplatin, not a curated reading list.
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