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VBI Vaccines' adult hepatitis B vaccine, licensed in the United States in 2021 and the European Union in 2022, and no longer marketed in either.
The FDA Purple Book lists Prehevbrio under BLA 125737 (VBI Vaccines (Delaware), Inc.), licensed on 30 November 2021 as 10 micrograms per millilitre, with a marketing status of discontinued in its October 2026 edition. The EMA authorised PreHevbri (EMEA/H/C/005466, VBI Vaccines B.V.) on 25 April 2022 for active immunisation against hepatitis B in adults; the EMA medicines report of 4 November 2026 gives its status as withdrawn.
Why it is a cancer vaccine: WHO estimates that hepatitis B caused 1.1 million deaths in 2024, mostly from cirrhosis and hepatocellular carcinoma (primary liver cancer), and that infection in infancy and early childhood becomes chronic in about 95% of cases. WHO recommends that all babies receive the vaccine as soon as possible after birth (within 24 hours), followed by two or three further doses (WHO fact sheet, 28 July 2026).
Recombinant hepatitis B surface antigen (the active substance the regulators name) trains the immune system to make antibodies against hepatitis B virus, preventing the infection that can lead to liver cancer.
1.PreHevbrio / PreHevbri (hepatitis B vaccine, adults, withdrawn) slips into a pocket on its target.
Licensed under BLA 125737 (FDA Purple Book) source
Authorised (EMEA/H/C/005466) source
| Region | Year | Indication |
|---|---|---|
| US | 2021 | Hepatitis B vaccine (recombinant), BLA 125737; discontinued |
| EU | 2022 | Active immunisation against hepatitis B in adults (EMEA/H/C/005466); withdrawn |
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Query for this drug: (TITLE:"PreHevbrio / PreHevbri" OR ABSTRACT:"PreHevbrio / PreHevbri" OR TITLE:"hepatitis B vaccine, adults, withdrawn" OR ABSTRACT:"hepatitis B vaccine, adults, withdrawn" OR TITLE:"PreHevbrio" OR ABSTRACT:"PreHevbrio" OR TITLE:"PreHevbri" OR ABSTRACT:"PreHevbri") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PreHevbrio / PreHevbri (hepatitis B vaccine, adults, withdrawn), not a curated reading list.
Shares Heplisav-B (hepatitis B vaccine, recombinant, adjuvanted), Engerix-B (hepatitis B vaccine, recombinant), Hepatitis B and C as cancer causes, HPV & HBV vaccination and the tags preventive-vaccine, hepatitis-b-vaccine.
Shares Heplisav-B (hepatitis B vaccine, recombinant, adjuvanted), Engerix-B (hepatitis B vaccine, recombinant), Hepatitis B and C as cancer causes, HPV & HBV vaccination and the tags preventive-vaccine, hepatitis-b-vaccine.
Shares Engerix-B (hepatitis B vaccine, recombinant), Hepatitis B and C as cancer causes, HPV & HBV vaccination and the tags preventive-vaccine, hepatitis-b-vaccine.
Shares Engerix-B (hepatitis B vaccine, recombinant), Hepatitis B and C as cancer causes, HPV & HBV vaccination and the tags preventive-vaccine, hepatitis-b-vaccine.
Shares Hepatitis B and C as cancer causes, HPV & HBV vaccination and the tags preventive-vaccine, hepatitis-b-vaccine.
Shares Hepatitis B and C as cancer causes, HPV & HBV vaccination and the tags preventive-vaccine, hepatitis-b-vaccine.
Shares Hepatitis B and C as cancer causes, HPV & HBV vaccination and the tags preventive-vaccine, hepatitis-b-vaccine.
Shares HPV & HBV vaccination and the tag preventive-vaccine.
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