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A nine-valent HPV vaccine produced in E. coli bacteria, authorised in China in May 2025; three years after vaccination, antibody levels in young women were no lower than with Gardasil 9.
Cecolin 9 is a second-generation nine-valent HPV vaccine derived from the WHO-prequalified Cecolin; the authors of its trial report state that it received marketing authorisation in China in May 2025. In a randomised, single-blind trial in Chinese women aged 18 to 26 (NCT04782895), type-specific immune responses were non-inferior to Gardasil 9 at month 7. In the three-year extension (NCT06197802), 403 of the 487 women enrolled (82.8%) were followed; the ratio of antibody concentrations (Cecolin 9 versus Gardasil 9) across the nine HPV types ranged from 0.78 to 1.91, meeting the non-inferiority margin for every type, and seropositivity ranged from 84.7% to 100.0% with Cecolin 9 and from 86.2% to 100.0% with Gardasil 9 (Zhong et al., Lancet Regional Health Western Pacific 2025). Antibody levels are a surrogate: the trial does not report cervical precancer or cancer outcomes. No WHO prequalification was found in the WHO list read on 4 November 2026.
Recombinant HPV L1 capsid proteins form virus-like particles that train the immune system to make antibodies against the HPV types the vaccine covers.
1.Cecolin 9 (nine-valent HPV vaccine made in E. coli) slips into a pocket on its target.
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| Region | Year | Indication |
|---|---|---|
| CN | 2025 | Marketing authorisation in China, May 2025, as reported by the trial authors |
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Query for this drug: (TITLE:"Cecolin 9" OR ABSTRACT:"Cecolin 9" OR TITLE:"nine-valent HPV vaccine made in E. coli" OR ABSTRACT:"nine-valent HPV vaccine made in E. coli" OR TITLE:"Cecolin9" OR ABSTRACT:"Cecolin9") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Cecolin 9 (nine-valent HPV vaccine made in E. coli), not a curated reading list.
Shares Cecolin (bivalent HPV vaccine, Xiamen Innovax), Oncogenic viruses, HPV & HBV vaccination and the tags preventive-vaccine, hpv-vaccine.
Shares HPV & HBV vaccination and the tag preventive-vaccine.
Shares Oncogenic viruses, HPV & HBV vaccination.
Shares Oncogenic viruses, HPV & HBV vaccination.
Shares Oncogenic viruses, HPV & HBV vaccination.
Shares Oncogenic viruses, HPV & HBV vaccination.
Shares HPV & HBV vaccination and the tag preventive-vaccine.
Shares HPV & HBV vaccination and the tag preventive-vaccine.
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