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Prexasertib is an experimental small molecule from Acrivon Therapeutics, in phase 2 trials for endometrial cancer, platinum-resistant ovarian cancer and head and neck squamous cell carcinoma.
Prexasertib (ACR-368, LY2606368) is a small molecule from Acrivon Therapeutics, with Eli Lilly as licensor (originator. A selective inhibitor of the DNA damage response checkpoint kinases CHK1 and CHK2. Acrivon uses its OncoSignature test on a tumour biopsy to pick patients predicted to respond. Its furthest stage is phase 2, for endometrial cancer, platinum-resistant ovarian cancer and head and neck squamous cell carcinoma. ClinicalTrials.gov registers it in 2 studies linked below. Registrational-intent phase 2b in endometrial cancer; Acrivon plans to start a phase 3 confirmatory trial in the first half of 2027 (Q2 2026 results release, 12 August 2026). Whether it works in people has not been established unless a trial below reports it.
1.Prexasertib slips into a pocket on CHEK1.
Background: ADC sequencing, Antigen escape (antigen loss, lineage switch), BCG-unresponsive, Castration-resistant prostate cancer (CRPC), Circulating tumour DNA (ctDNA). Also on OnCo: Resistance: how tumours escape each drug class · Lines of therapy.
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Query for this drug: (TITLE:"Prexasertib" OR ABSTRACT:"Prexasertib" OR TITLE:"ACR-368" OR ABSTRACT:"ACR-368" OR TITLE:"LY2606368" OR ABSTRACT:"LY2606368") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Prexasertib, not a curated reading list.
Shares Acrivon Therapeutics and the tag pipeline.
Shares Acrivon Therapeutics and the tag pipeline.
Shares Acrivon Therapeutics and the tag pipeline.
Shares Endometrial cancer, Head and neck squamous cell carcinoma and the tag pipeline.
Shares Endometrial cancer, Head and neck squamous cell carcinoma and the tag pipeline.
Shares Endometrial cancer, Head and neck squamous cell carcinoma and the tag pipeline.
Shares Endometrial cancer, Head and neck squamous cell carcinoma and the tag pipeline.
Shares Endometrial cancer, Head and neck squamous cell carcinoma and the tag pipeline.
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