Repotrectinib
A ROS1 and NTRK pill that also works after other ROS1 drugs fail, with dizziness as its signature side effect.
TRIDENT-1: ORR 79% in TKI-naive and 38% in TKI-pretreated ROS1+ NSCLC, covering the G2032R solvent-front mutation. Approved November 2023 (ROS1) and June 2024 (NTRK, tumour-agnostic). Zidesamtinib (2026) offers a TRK-sparing alternative with fewer neurologic effects.
- Medicare
- Part D (self-administered)
Oral, self-administered, so it is a Part D drug: covered through a stand-alone Part D plan or Medicare Advantage drug benefit, usually on the specialty tier with 25 to 33% coinsurance until the annual cap ($2,000 in 2025, $2,100 in 2026).
- Commercial insurance
- covered with prior authorisation
Covered for FDA-labelled and NCCN-listed uses, but almost always behind prior authorisation confirming diagnosis, biomarker and line of therapy; dispensed through a specialty pharmacy.
- Assistance programmes
- BMS Access Support
- Bristol Myers Squibb Patient Assistance Foundation
- PAN Foundation — Disease-specific co-pay and premium funds; open and closed funds change monthly.
- HealthWell Foundation
- CancerCare Co-Payment Assistance Foundation
- Patient Advocate Foundation Co-Pay Relief
Part D out-of-pocket capped at $2,000 (2025) / $2,100 (2026). Medicare patients cannot use manufacturer co-pay cards; charity funds (PAN, HealthWell, CancerCare) and the Extra Help subsidy are the routes.
Sources: Medicare.gov: Drug coverage (Part D) · Medicare.gov: Costs for Medicare drug coverage (annual out-of-pocket cap). Not medical or financial advice; verify with your plan.
- Notes
- EU-licensed 2025 for ROS1-positive NSCLC and NTRK tumours; UK licence and NICE position not yet researched.
Sources: NICE search: repotrectinib. Funding decisions are indication-specific and change monthly; verify with NICE and your treating team.
Approvals
| Region | Year | Indication |
|---|---|---|
| US | 2023 | ROS1+ locally advanced or metastatic NSCLC |
| US | 2024 | NTRK-fusion solid tumours (tumour-agnostic) |
Trials
topRecruiting now (live from ClinicalTrials.gov)
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Latest papers
topQuery for this drug: (TITLE:"Repotrectinib" OR ABSTRACT:"Repotrectinib" OR TITLE:"Augtyro" OR ABSTRACT:"Augtyro") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Repotrectinib, not a curated reading list.
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