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The Brisbane experiment in which Jian Zhou and Ian Frazer made empty shells of the HPV16 virus in cells. Virus-like particles of this kind are what HPV vaccines are made of.
Working at the Lions Human Immunology Laboratory at the Princess Alexandra Hospital in Brisbane, Jian Zhou, Ian Frazer and colleagues designed a recombinant vaccinia virus, pLC201VV, to express the two late (capsid) genes of HPV type 16, L1 and L2, together in epithelial cells. Cells making both proteins produced 40-nanometre virus-like particles with a density of 1.31 g/ml in their nuclei, while cells making either protein alone did not. Partly purified particles were made of capsomeres resembling those of HPV and contained glycosylated L1 capsid protein. The authors noted that particles made this way could be a safe source of material for developing a vaccine.
Virus-like particles carry the shape of the virus without its DNA, so they can train the immune system without any risk of infection. That principle, worked on in parallel in the United States, is the basis of the HPV vaccines now given to adolescents in Australia's school programme.
Shares Ian Frazer, Nonavalent HPV vaccine, HPV & HBV vaccination, Cervical cancer.
Shares Ian Frazer, HPV & HBV vaccination, Cervical cancer.
Shares Jian Zhou, Ian Frazer, Nonavalent HPV vaccine, HPV & HBV vaccination.
Shares Ian Frazer, Nonavalent HPV vaccine, HPV & HBV vaccination, Cervical cancer.
Shares Ian Frazer, HPV & HBV vaccination, Cervical cancer.
Shares Ian Frazer, HPV & HBV vaccination, Cervical cancer.
Shares Nonavalent HPV vaccine, HPV & HBV vaccination, Cervical cancer.
Shares Nonavalent HPV vaccine, HPV & HBV vaccination, Cervical cancer.
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