IL2RG
IL2RG (Cytokine receptor common subunit gamma) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Skin cancer, Renal cell carcinoma, Leukaemia and 3 more.
Overview
Common subunit for the receptors for a variety of interleukins. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15.
Open Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes literature 0.90, animal model 0.54, genetic association 0.00, clinical 0.96).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · IL2RG (Cytokine receptor common subunit gamma) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Skin cancer, Renal cell carcinoma, Leukaemia and 3 more.
- 1 · What it is
IL2RG (Cytokine receptor common subunit gamma) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Skin cancer, Renal cell carcinoma, Leukaemia and 3 more.
- 2 · What goes wrong in cancer
Common subunit for the receptors for a variety of interleukins. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15.
- 3 · How drugs use it
No product in this corpus aims at IL2RG yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:6010 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P31785 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000147168 (association with cancer (MONDO_0004992) 0.62; per-cancer scores at or above 0.5: renal cell carcinoma 0.54, melanoma 0.55, non-Hodgkin lymphoma 0.51, skin cancer 0.56, leukaemia 0.54, primary cutaneous T-cell non-Hodgkin lymphoma 0.55 (GraphQL API, CC0))
Biology
Common subunit for the receptors for a variety of interleukins. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15. Location: Cell membrane; Cell surface (UniProt). Locus Xq13.1 (HGNC).
- Skin cancer: Open Targets association 0.56 with skin cancer (MONDO_0002898)
- Renal cell carcinoma: Open Targets association 0.54 with renal cell carcinoma (MONDO_0005086)
- Leukaemia: Open Targets association 0.54 with leukaemia (MONDO_0005059)
- Non-Hodgkin lymphoma: Open Targets association 0.51 with non-Hodgkin lymphoma (MONDO_0018908)
- Melanoma: Open Targets association 0.55 with melanoma (MONDO_0005105)
- Cutaneous T-cell lymphoma: Open Targets association 0.55 with primary cutaneous T-cell non-Hodgkin lymphoma (MONDO_0000607)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.96. Evidence tier "approved-drug" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"IL2RG" OR ABSTRACT:"IL2RG" OR TITLE:"interleukin 2 receptor subunit gamma" OR ABSTRACT:"interleukin 2 receptor subunit gamma" OR TITLE:"Cytokine receptor common subunit gamma" OR ABSTRACT:"Cytokine receptor common subunit gamma" OR TITLE:"CD132" OR ABSTRACT:"CD132" OR TITLE:"SCIDX1" OR ABSTRACT:"SCIDX1" OR TITLE:"IMD4" OR ABSTRACT:"IMD4") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about IL2RG, not a curated reading list.
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