IL2RB
IL2RB (Interleukin-2 receptor subunit beta) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Skin cancer, Leukaemia, Renal cell carcinoma and 3 more.
Overview
Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15.
Open Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes literature 0.84, animal model 0.52, genetic association 0.00, clinical 0.96). In OnCo, 1 product record names it (Bempegaldesleukin).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · IL2RB (Interleukin-2 receptor subunit beta) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Skin cancer, Leukaemia, Renal cell carcinoma and 3 more.
- 1 · What it is
IL2RB (Interleukin-2 receptor subunit beta) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Skin cancer, Leukaemia, Renal cell carcinoma and 3 more.
- 2 · What goes wrong in cancer
Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2.
- 3 · How drugs use it
No product in this corpus aims at IL2RB yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:6009 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P14784 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000100385 (association with cancer (MONDO_0004992) 0.62; per-cancer scores at or above 0.5: renal cell carcinoma 0.52, melanoma 0.55, non-Hodgkin lymphoma 0.51, skin cancer 0.56, leukaemia 0.53, primary cutaneous T-cell non-Hodgkin lymphoma 0.55 (GraphQL API, CC0))
Biology
Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15. Location: Cell membrane (UniProt). Locus 22q12.3 (HGNC).
- Skin cancer: Open Targets association 0.56 with skin cancer (MONDO_0002898)
- Leukaemia: Open Targets association 0.53 with leukaemia (MONDO_0005059)
- Renal cell carcinoma: Open Targets association 0.52 with renal cell carcinoma (MONDO_0005086)
- Non-Hodgkin lymphoma: Open Targets association 0.51 with non-Hodgkin lymphoma (MONDO_0018908)
- Cutaneous T-cell lymphoma: Open Targets association 0.55 with primary cutaneous T-cell non-Hodgkin lymphoma (MONDO_0000607)
- Melanoma: Open Targets association 0.55 with melanoma (MONDO_0005105)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.96. Evidence tier "approved-drug" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"IL2RB" OR ABSTRACT:"IL2RB" OR TITLE:"interleukin 2 receptor subunit beta" OR ABSTRACT:"interleukin 2 receptor subunit beta" OR TITLE:"Interleukin-2 receptor subunit beta" OR ABSTRACT:"Interleukin-2 receptor subunit beta" OR TITLE:"CD122" OR ABSTRACT:"CD122" OR TITLE:"IL15RB" OR ABSTRACT:"IL15RB") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about IL2RB, not a curated reading list.
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