CD112 (nectin-2)
CD112 is a widespread cell-adhesion molecule that can either encourage a T cell (through CD226) or hold it back (through PVRIG and TIGIT), depending on which receptor grabs it first.
Overview
NECTIN2 (chromosome 19q13.32) is a modulator of T-cell signalling that acts as a costimulator or a coinhibitor depending on the receptor it binds: through CD226 it stimulates proliferation and the production of IL-2, IL-5, IL-10, IL-13 and interferon gamma, through PVRIG it inhibits proliferation, and the two interactions are competitive; it is ubiquitously expressed and a probable cell-adhesion protein (UniProt Q92692). TIGIT binds PVR (CD155) or NECTIN2 (CD112) on antigen-presenting cells and sends inhibitory signals to the T cell or NK cell (UniProt Q495A1).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · CD112 is a widespread cell-adhesion molecule that can either encourage a T cell (through CD226) or hold it back (through PVRIG and TIGIT), depending on which receptor grabs it first.
- 1 · What it is
CD112 is a widespread cell-adhesion molecule that can either encourage a T cell (through CD226) or hold it back (through PVRIG and TIGIT), depending on which receptor grabs it first.
- 2 · What goes wrong in cancer
The second ligand of the TIGIT axis and the sole established ligand of PVRIG.
- 3 · How drugs use it
No product in this corpus aims at CD112 (nectin-2) yet. Checkpoint drugs are antibodies that cover one side of an immune ‘stand down’ handshake so T cells stay active.
External identifiers
Sources: HGNC HGNC:9707 (approved symbol, name, aliases and cross-references); UniProt Q92692 (protein name, function and tissue specificity)
Biology
The second ligand of the TIGIT axis and the sole established ligand of PVRIG.
- Ubiquitous (UniProt Q92692)
Notes
top- Prevalence not recorded: HGNC and UniProt carry no positivity rates.
Latest papers
topQuery for this target: (TITLE:"CD112" OR ABSTRACT:"CD112" OR TITLE:"nectin-2" OR ABSTRACT:"nectin-2" OR TITLE:"NECTIN2" OR ABSTRACT:"NECTIN2" OR TITLE:"PVRL2" OR ABSTRACT:"PVRL2" OR TITLE:"PRR2" OR ABSTRACT:"PRR2" OR TITLE:"HVEB" OR ABSTRACT:"HVEB") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CD112 (nectin-2), not a curated reading list.
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