Boltz-1 / Boltz-2 (MIT, open)
Open-source structure models that match AlphaFold 3, with Boltz-2 also predicting how strongly a drug binds.
Boltz-1 (2024) reproduced AF3-level accuracy under MIT licence; Boltz-2 (2025, with Recursion) added binding-affinity prediction approaching physics-based FEP at a fraction of the cost.
Generic schematic · not to scale · placeholder for the drug discovery front
Guide RNA library · Knockout → dependency
How it works
Diffusion structure model with affinity head.
Strengths
- Open
- Affinity prediction
Limitations
- Affinity accuracy varies by target class
Since
2024
Latest papers
topLatest papers · live from Europe PMC
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