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ATX-295 is an experimental oral small molecule from Accent Therapeutics, in phase 1 trials for high-grade serous ovarian cancer, squamous non-small cell lung cancer and advanced or metastatic solid tumours.
ATX-295 is an oral small molecule from Accent Therapeutics. An inhibitor of KIF18A, a motor protein needed for cell division in tumours with chromosomal instability; the company says aneuploid cancer cells die quickly while cells with normal chromosome numbers are spared. Its furthest stage is phase 1, for high-grade serous ovarian cancer (including platinum-resistant), squamous non-small cell lung cancer and advanced or metastatic solid tumours. ClinicalTrials.gov registers it in one study linked below. Phase 1/2 NCT06799065 recruiting; Accent retains full worldwide rights. Whether it works in people has not been established unless a trial below reports it.
An inhibitor of KIF18A, a motor protein needed for cell division in tumours with chromosomal instability; the company says aneuploid cancer cells die quickly while cells with normal chromosome numbers are spared. Connects to KIF18A.
1.ATX-295 slips into a pocket on KIF18A.
Background: ADC sequencing, Antigen escape (antigen loss, lineage switch), BCG-unresponsive, Castration-resistant prostate cancer (CRPC), Circulating tumour DNA (ctDNA). Also on OnCo: Resistance: how tumours escape each drug class · Lines of therapy.
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Query for this drug: (TITLE:"ATX-295" OR ABSTRACT:"ATX-295") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ATX-295, not a curated reading list.
Shares Accent Therapeutics, Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares Accent Therapeutics, Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares Ovarian cancer, Metastatic cancer (cancer that has spread), Non-small-cell lung cancer and the tag pipeline.
Shares Ovarian cancer, Non-small-cell lung cancer and the tag pipeline.
Shares Ovarian cancer, Non-small-cell lung cancer and the tag pipeline.
Shares Ovarian cancer, Metastatic cancer (cancer that has spread), Non-small-cell lung cancer and the tag pipeline.
Shares Ovarian cancer, Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares Ovarian cancer, Metastatic cancer (cancer that has spread) and the tag pipeline.
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