ATX-898 is an experimental small molecule from Antares Therapeutics, in phase 1 trials for advanced solid tumours, platinum-resistant ovarian cancer and other gynaecological cancers and other cancers.
ATX-898 is a small molecule (registry lists it as a drug; the company does not publish the modality for this code) from Antares Therapeutics. Not disclosed. The registry describes a first-in-human study of ATX-898 alone and with other anticancer drugs; no source reached names its target. Its furthest stage is phase 1, for advanced solid tumours, platinum-resistant ovarian cancer, other gynaecological cancers and HR-positive HER2-negative breast cancer (with fulvestrant plus abemaciclib or ribociclib). ClinicalTrials.gov registers it in one study linked below. Phase 1/2 study NCT07767474 recruiting; actual start 31 August 2026 (ClinicalTrials.gov). Whether it works in people has not been established unless a trial below reports it.
Not disclosed. The registry describes a first-in-human study of ATX-898 alone and with other anticancer drugs; no source reached names its target.
1.ATX-898 slips into a pocket on its target.
Background: ADC sequencing, Antigen escape (antigen loss, lineage switch), BCG-unresponsive, Castration-resistant prostate cancer (CRPC), Circulating tumour DNA (ctDNA). Also on OnCo: Resistance: how tumours escape each drug class · Lines of therapy.
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Query for this drug: (TITLE:"ATX-898" OR ABSTRACT:"ATX-898") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ATX-898, not a curated reading list.
Shares Antares Therapeutics and the tag pipeline.
Shares Antares Therapeutics and the tag pipeline.
Shares Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares Metastatic cancer (cancer that has spread) and the tag pipeline.
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