Loading
PFL-241 is an experimental small molecule kinase inhibitor from Antares Therapeutics, in phase 1 trials for non-small cell lung cancer resistant to EGFR tyrosine kinase inhibitors.
PFL-241 (STX-241) is a small molecule kinase inhibitor from Antares Therapeutics, with Pierre Fabre Laboratories as licensee. A mutant-specific, brain-penetrant fourth-generation EGFR inhibitor meant to address the C797S resistance mutation in non-small cell lung cancer. Its furthest stage is phase 1, for non-small cell lung cancer resistant to EGFR tyrosine kinase inhibitors. ClinicalTrials.gov registers it in one study linked below. Phase 1/2 NCT06567015 recruiting, sponsored by Pierre Fabre Medicament. Whether it works in people has not been established unless a trial below reports it.
A mutant-specific, brain-penetrant fourth-generation EGFR inhibitor meant to address the C797S resistance mutation in non-small cell lung cancer. Connects to EGFR.
1.PFL-241 slips into a pocket on EGFR.
Background: ADC sequencing, Antigen escape (antigen loss, lineage switch), BCG-unresponsive, Castration-resistant prostate cancer (CRPC), Circulating tumour DNA (ctDNA). Also on OnCo: Resistance: how tumours escape each drug class · Lines of therapy.
Country and place are remembered in this browser only. A postcode is sent to OpenStreetMap's Nominatim service to find coordinates when you press the button; nothing else leaves your device.
Query for this drug: (TITLE:"PFL-241" OR ABSTRACT:"PFL-241" OR TITLE:"STX-241" OR ABSTRACT:"STX-241") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PFL-241, not a curated reading list.
Shares Antares Therapeutics, Pierre Fabre, EGFR, Non-small-cell lung cancer and the tag pipeline.
Shares Pierre Fabre, EGFR, Non-small-cell lung cancer and the tag pipeline.
Shares EGFR, Non-small-cell lung cancer and the tag pipeline.
Shares EGFR, Non-small-cell lung cancer and the tag pipeline.
Shares EGFR, Non-small-cell lung cancer and the tag pipeline.
Shares Pierre Fabre and the tag pipeline.
Shares EGFR, Non-small-cell lung cancer and the tag pipeline.
Shares Antares Therapeutics and the tag pipeline.
Every source this page cites, grouped by who published it. Grouping is read from the web address, not assigned by hand.
A source that has moved or gone is reported by the weekly link check. /audit/